| Day | Date | Opponent | Location | Outcome/Time |
| Fri | 11/11/05 | California (Pa) (exh.) | Petersen Events Center | W, 85-48
Recap | Box Score |
| Tue | 11/15/05 | OGBR Legends (exh.) | Petersen Events Center | W, 77-60
Recap | Box Score | Gametracker |
| Fri | 11/18/05 | William & Mary (Banknorth Classic) | Burlington, Vt. | W, 76-49
Recap | Box Score |
| Sat | 11/19/05 | Vermont (TD Banknorth Classic) | Burlington, Vt. | W, 70-49
Recap | Box Score |
| Tue | 11/22/05 | Akron | Petersen Events Center | W, 91-46
Recap | Box Score | Gametracker |
| Sat | 11/26/05 | Towson (Pitt Thanksgiving Tournament) | Petersen Events Center | W, 69-50
Recap | Box Score | Photo Gallery | Gametracker |
| Sun | 11/27/05 | Missouri (Pitt Thanksgiving Tournament) | Petersen Events Center | L, 69-60
Box Score | Photo Gallery | Gametracker |
| Wed | 11/30/05 | Duquesne | Petersen Events Center | W, 82-69
Recap | Box Score | Photo Gallery | Gametracker |
| Fri | 12/02/05 | Penn State | University Park, PA | L, 69-60
Recap | Box Score |
| Tue | 12/06/05 | Robert Morris | Moon Twp., Pa. | W, 66-36
Recap | Box Score |
| Thu | 12/08/05 | Syracuse | Petersen Events Center | W, 67-55
Recap | Box Score | Gametracker |
| Mon | 12/19/05 | Pepperdine | Malibu, Calif. | W, 79-64
Recap | Box Score | Gametracker |
| Thu | 12/22/05 | San Diego State | San Diego, Calif. | W, 78-56
Recap | Box Score | Gametracker |
| Fri | 12/30/05 | St. Bonaventure | Petersen Events Center | W, 68-55
Recap | Box Score | Gametracker |
| Tue | 01/03/06 | DePaul | Chicago, Ill. | L, 81-75
Recap | Final Stats |
| Sun | 01/08/06 | USF | Petersen Events Center | W, 66-64
Recap | Box Score | Photo Gallery |
| Wed | 01/11/06 | St. John's (NY) | Jamaica, N.Y. | L, 72-55
Box Score |
| Sat | 01/14/06 | Providence | Petersen Events Center | W, 75-65
Recap | Box Score | Photo Gallery |
| Wed | 01/18/06 | Marquette | Milwaukee, Wis. | L, 71-62
Recap | Box Score |
| Sat | 01/21/06 | Connecticut | Petersen Events Center | L, 65-54
Recap | Box Score | Photo Gallery | Gametracker |
| Sat | 01/28/06 | Villanova | Villanova, Pa. | W, 59-56
Recap | Box Score | Gametracker |
| Wed | 02/01/06 | Georgetown | Petersen Events Center | W, 79-62
Recap | Box Score | Gametracker |
| Sat | 02/04/06 | Cincinnati | Cincinnati, Ohio | W, 64-63
Recap | Box Score | Gametracker |
| Wed | 02/08/06 | Louisville | Petersen Events Center | L, 71-63
Recap | Box Score | Gametracker |
| Sat | 02/11/06 | USF | Tampa, Fla. | W, 60-58
Recap | Box Score |
| Tue | 02/14/06 | Seton Hall | Petersen Events Center | W, 58-56
Recap | Box Score | Photo Gallery | Gametracker |
| Sun | 02/19/06 | West Virginia | Morgantown, W.Va. | W, 62-58
Recap | Box Score | Gametracker |
| Sat | 02/25/06 | Rutgers | Petersen Events Center | L, 65-50
Recap | Box Score | Photo Gallery | Gametracker |
| Tue | 02/28/06 | Notre Dame | Notre Dame, Ind. | L, 72-65
Recap | Box Score | Gametracker |
| Sat | 03/04/06 | Cincinnati
(Big East Tournament - First Round) | Hartford, Conn. | W, 77-62
Recap | Box Score |
| Sun | 03/05/06 | DePaul
(Big East Tournament - Quarterfinals) | Hartford, Conn. | L, 69-46
Recap | Box Score | Gametracker |
| Sat | 03/18/06 | Delaware (WNIT First Round) | Petersen Events Center | W, 64-57
Recap | Box Score | Gametracker |
| Wed | 03/22/06 | Mississippi (WNIT Second Round) | Fitzgerald Field House | W, 85-76
Recap | Box Score | Gametracker |
| Fri | 03/24/06 | Virginia (WNIT Quarterfinals) | Fitzgerald Field House | W, 68-58
Recap | Box Score | Gametracker |
| Mon | 03/27/06 | Marquette (WNIT Semifinals) | Milwaukee, WI | L, 77-64
Recap | Box Score |
